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Limitations and challenges in clinical translation Although this study has confirmed that AAP NPs can effectively inhibit COC by targeting and inducing ferroptosis, their limitations and the severe challenges in clinical translation must be fully recognized and elaborated

Histologic remission 2 * Several definitions of histologic remission in ulcerative colitis have been described

The number of B lymphocytes and the levels of serum immunoglobulin and antibody analyzed during the aging

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